Antigen Selection Mechanisms Control T Cell Immunity Against Bacteria

Grant number: DP200103110 | Funding period: 2020 - 2023

Completed

Abstract

CD4+ T (T helper) cells are required to control many important bacterial infections. This Project aims to identify the key targets of CD4+ T cells responding to a model bacterial infection, and to correlate potential antigen effectiveness with native expression, antigen presentation, and the function of antigen-specific CD4+ T cells over time. Our validated experimental 'pipeline' has unprecedented potential to define potent CD4+ T cell antigens within the thousands of proteins expressed by a bacterial pathogen. Our unbiased analysis may help establish the rules that define effective antigenicity. Our work will improve the understanding of bacterial immunity, and inform future design of T-ce..

View full description

Related publications (4)

Scholarly works icon

Vaccine-induced inflammation and inflammatory monocytes promote CD4 T cell-dependent immunity against murine salmonellosis

Nancy Wang, Timothy A SCOTT, Andreas KUPZ, Meghanashree M Shreenivas, Newton G Peres, Dianna M Hocking, Chenying YANG, Leila Jebeli, Lynette Beattie, Joanna R Groom, Thomas P Pierce, Linda M Wakim, Sammy Bedoui, Richard A Strugnell

2023-09-21

Prior infection can generate protective immunity against subsequent infection, although the efficacy of such immunity can vary con..

Scholarly works icon

LPS O Antigen Plays a Key Role in Klebsiella pneumoniae Capsule Retention

S Singh, JJ Wilksch, RA Dunstan, A Mularski, N Wang, D Hocking, L Jebeli, H Cao, A Clements, AWJ Jenney, T Lithgow, RA Strugnell

2022-08-01

Despite the importance of encapsulation in bacterial pathogenesis, the biochemical mechanisms and forces that underpin retention o..

Scholarly works icon

CD4 T cell immunity to Salmonella is transient in the circulation

NG Peres, N Wang, P Whitney, S Engel, MM Shreenivas, I Comerford, DM Hocking, AB Erazo, I Förster, A Kupz, T Gebhardt, SR McColl, SJ McSorley, S Bedoui, RA Strugnell

2021-10-01

While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD..

Scholarly works icon

CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination

AB Erazo, N Wang, L Standke, AD Semeniuk, L Fülle, SC Cengiz, M Thiem, H Weighardt, RA Strugnell, I Förster

2021-09-01

Introduction: Salmonella spp. are a recognized and global cause of serious health issues from gastroenteritis to invasive disease...

University of Melbourne Researchers